Thrombose cible

Targeted thrombosis by tissue factor polypeptides

Abstract

L'invention concerne des compositions et des méthodes qui permettent d'amorcer une thrombose dirigée dans le système vasculaire d'une tumeur. L'invention concerne en particulier des thrombogènes du système vasculaire des tissus cibles (STVT) qui peuvent induire une thrombose cible, un infarctus, et la destruction de tissus cibles, tels que, par exemple, des tumeurs. L'invention concerne en outre l'utilisation des compositions et méthodes de l'invention pour traiter des tumeurs.
The invention provided compositions and methods to initiate site-specific thrombosis in tumor vasculature. The invention particularly provides Selective Tissue Vascular Thrombogens (STVTs) that can targeted thrombosis, infarction and destruction of selected tissues, for exemple, tumors. The present invention also provides methods for using the disclosed compositions and methods to treat tumors.

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